To use a medkit , LMB (left mouse button) click on the creature you intend to heal. Then open your inventory, RMB (right mouse button) click on the medkit, and select Use from the pop-up context menu. Alternately, you can LMB, click, hold, and drag the medkit to your Action Bar Window (this is the window at the bottom of your screen with a series of empty button slots) and LMB click on it after selecting the target. To use it on yourself, do not select a target.
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